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New single-cell sequencing method has the potential to boost efforts to find cancer-fighting drugs. Most cancerous tissue consists of rapidly dividing cells with a limited capacity for self-renewal, meaning that the bulk of cells stop reproducing after a certain number of divisions. However, cancer stem cells can replicate indefinitely, fuelling long-term cancer growth and driving relapse. Cancer stem cells that elude conventional treatments like chemotherapy are one of the reasons patients initially enter remission but relapse soon after. However, cancer stem cells are difficult to isolate and study because of their low abundance and similarity to other types of stem cell.
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